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Stopping rules: Discontinue GHK-Cu if free copper exceeds 25 mcg/dL, 24-hour urine copper exceeds 100 mcg/day, ALT or AST rises to more than 3 times the patient's baseline value, or clinical signs of copper toxicity appear

Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors